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Sep. 18, 2021

DS34942424: A Potent Oral Non-Opioid Receptor Analgesic

DS34942424

potent oral non-opioid receptor analgesic oral activity in pain model, unknown mech. Inspired by natural product, conolidine Bioorg. Med. Chem., Aug. 8, 2020 Daiichi Sankyo, Tokyo, JP

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Drug Hunter Team

DS34942424 is a potent oral analgesic discovered using the natural product conolidine as a starting point. While the authors were able to demonstrate that the compound does not exert its activity through the mu-opioid receptor, the mechanism of action is not understood. The identification of non-opioid analgesics are an area of intense [...]

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