dotinurad (FYU-981) potently inhibits uric acid uptake by renal proximal tubule epithelial cells, increasing uric acid urinary secretion which can help hyperuricemic conditions like gout. The mechanism of action is believed to be inhibition of the URAT1 organic anion transporter which mediates uric acid reabsorption. Benzbromarone has been [...]
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Sep. 18, 2021
Dotinurad: A Potent Uric Acid Uptake Inhibitor
dotinurad (FYU-981)
uric acid uptake (URAT1 transporter) inhibitor approved as new uricosuric med. In JP optimized to avoid mitochondrial toxicity ACS Med. Chem. Lett., Jul. 20, 2020 Fuji Yakuhin, Saitama, JP
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