Tumors can evade the immune system through the recruitment of regulatory T cells (Treg) which limit the activation and expansion of effector T cells (Teff). IKZF2 (Helios) is an Ikaros transcription factor family member that is expressed in a majority of Treg cells [...]
A Treg-Modulating IKZF2 (Helios) Glue Degrader for Cancer Immunotherapy
DKY709
oral IKZF2-selective molecular glue degrader Ph. I/Ib for adv. solid tumors opt. of pomalidomide analog Cell Chemical Biology, March 1, 2023 Novartis, Cambridge, MA