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Sep. 18, 2021

Compound 7f: An Oral Toll-Like Receptors 7/8/9 Antagonist

"compound 7f"

oral toll-like receptors 7/8/9 antagonist oral efficacy in autoimmune disease models from cell-based screen and opt. ACS Med. Chem. Lett., Jul. 29, 2020 Bristol-Myers Squibb, Princeton, NJ

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Drug Hunter Team

“compound 7f” is an antagonist of the endosomal TLRs 7/8/9, which induce inflammation in response to internalized single-stranded RNA or hypomethylated double-stranded DNA. Potency and selectivity within endosomal TLR’s (3, 7, 8, 9) and against cell-surface TLR’s (1, 2, 4, 5, 6) has been difficult to achieve . Compound 7f has single-digit [...]

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