“Compound 6f” is a potent macrocyclic factor XIa inhibitor (<1 nM) that is highly selective against other serine proteases and has excellent oral PK (high bioavailability, low clearance).
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Sep. 18, 2021
Orally Available Macrocycle is a Highly Selective Factor XIa Inhibitor
"Compound 6f"
selective factor XIa serine protease inhibitor oral in higher species, eff. in thrombosis model from PK optimization of prior series J. Med. Chem., May 26, 2020 Bristol Myers Squibb, Princeton, NJ
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