The Dompé Farmaceutici TRPM8 blocker, compound 59 is a potent (IC50 = 11 nM) compound for painful ocular conditions, with ocular efficacy in a preclinical behavioral model. TRPM8 is a cation channel which is the predominant in mammalian cold thermosensor and it is activated by well-known molecules like menthol, eucalyptol, and geraniol [...]
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Dec. 20, 2021
compound 59: a TRPM8 blocker
compound 59
TRPM8 blocker for ocular administration effective w/ ocular admin. in animal model cell-based screen. and opt. of thiazoles series Journal of Medicinal Chemistry Dompé Farmaceutici S.p.A