© Rosalind Scientific LLC 2018-2022
© Rosalind Scientific LLC, 2018-2022
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oral selective VPS34 kinase inhibitor
discontinued due to potential toxicity
SBDD and SAR optimization
Journal of Medicinal Chemistry
11. The Genentech VPS34 kinase inhibitor, compound 5, is a selective kinase inhibitor that is unusually polar for a kinase inhibitor (logD = 1.0, PPB = 23%) but maintains low clearance.…
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