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5-HT2 antagonist and 5-HT7 inverse agonist
brain penetrant, oral efficacy in rodent models
backup candidate to JNJ-18038683
Bioorg. Med. Chem. Lett., Nov. 7, 2020
Janssen, San Diego, CA
“compound 4j” (Janssen (JNJ) brain-penetrant in vivo 5-HT2 antagonist and 5-HT7 inverse agonist, backup candidate)
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