Chemical structure of molecule SJ995973 compound 4c

degrader with simpler CRBN warhead

BRD4 DC50 = 0.87 nM, Dmax = 99%

from structure-based design

Angewandte Chemie Int. Ed.

Saint Jude Children’s Hospital, Memphis, TN

 The bifunctional degrader, SJ995973, was nominated by Joachim Rudolph. “Instead of the thalidomide-based cereblon binder present in the established BET degrader tool dBET1, SJ995973 uses a novel cereblon binder containing a…

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