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Jan. 17, 2022

“Compound 43b” is a RBP4-TTR Protein-Protein Interaction (PPI) Inhibitor

“compound 43b”

RBP4 reducer targeting RBP4/TTR PPI preclinical, in vivo RBP4 reduction from HTS and optimization Bioorganic and Medicinal Chemistry Takeda, Fujisawa, JP

drughunter.com
Drug Hunter Team

Retinol-binding protein 4 (RBP4) is the sole carrier for retinol (vitamin A). It may also play a role in diabetes and reduction of RBP4 may be beneficial for the ocular disease AMD. Belite Bio had a Ph. III trial ongoing for an oral RBP4 antagonist (LBS-008, tinlarebant ) in Stargardt Disease and intends to start a Ph. III trial for AMD in [...]

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