intravenous PKG1α activator
satisfactory in vivo rat PK profile
from 2.9 M compounds HTS, SBDD and opt
J. Med. Chem.
Merck & Co., Inc., South San Francisco, CA
Context. “Compound 33” (Merck) is a cGMP-dependent protein kinase G1α (PKG1α) activator cGMP modulation is considered one of the most promising approaches for cardiovascular drug discovery with >30 agents…