intravenous PKG1α activator

satisfactory in vivo rat PK profile

from 2.9 M compounds HTS, SBDD and opt

J. Med. Chem.

Merck & Co., Inc., South San Francisco, CA

Compound 33 Chemical Structure intravenous PKG1α activator - Merck & Co., Inc., South San Francisco, CA

Context. “Compound 33” (Merck) is a cGMP-dependent protein kinase G1α (PKG1α) activator cGMP modulation is considered one of the most promising approaches for cardiovascular drug discovery with >30 agents…

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