“Compound 25,” inhibits HPK1 via a rare “P-loop folded” active site conformation. The molecule was nominated by reviewer Julien Lefranc, and structural biologist Yoana Dimitrova shares some insight here:…
Drug Hunter
Drug Hunter
“Compound 25,” inhibits HPK1 via a rare “P-loop folded” active site conformation. The molecule was nominated by reviewer Julien Lefranc, and structural biologist Yoana Dimitrova shares some insight here:…