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compound 20p

Recent Publication

FXR nucl. receptor + TGR5 GPCR dual agonist

dual in vivo effects at 100 mpk PO

from merger of literature agonist fragments

Sci. Rep., Apr. 28, 2021

Fuji Yakuhin Co., Ltd., Saitama, JP

The Fuji Yakuhin FXR/TGR5 non-bile acid dual agonist, compound 20p, simultaneously activates the FXR nuclear receptor and the unrelated TGR5 GPCR receptor when dosed orally in vivo. FXR has been…


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