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“Compound 20”

Recent Publication

long-acting RIPK2 degrader (SC admin.)

in vivo degradation of RIPK2 over 60 days

IAP binder linked to RIPK2 binder

Journal of Medicinal Chemistry

GlaxoSmithKline, Stevenage, UK

The GSK RIPK2 PROTAC, “compound 20”, demonstrates in vivo degradation of RIPK2 over 60 days after a single compound dose when administered SC in slow-release PLGA microparticles. This degrader…

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“Compound 20”

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