© Rosalind Scientific LLC 2018-2022
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long-acting RIPK2 degrader (SC admin.)
in vivo degradation of RIPK2 over 60 days
IAP binder linked to RIPK2 binder
Journal of Medicinal Chemistry
GlaxoSmithKline, Stevenage, UK
The GSK RIPK2 PROTAC, “compound 20”, demonstrates in vivo degradation of RIPK2 over 60 days after a single compound dose when administered SC in slow-release PLGA microparticles. This degrader…
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