“Compound 20” (Gedeon Richter) is an oral α5-GABA A receptor negative allosteric modulator (NAM) being developed for cognitive disorders . GABA receptor NAMs are known to exert effects opposite to the anxiolytic and anticonvulsant effects of positive allosteric modulators. However, NAM agents targeting α5-GABA A receptors, which have [...]
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Jun. 18, 2022
An Oral α5-GABA A Receptor Negative Allosteric Modulator (NAM)
compound 20
oral α5-GABAA receptor NAM oral efficacy in CIAS rodent models scaffold hopping from literature starting point J. Med. Chem., May 18, 2022 Gedeon Richter, Budapest, HU
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