TEAD transcription factor lipidation modulator
orally active in xenograft model
from 1M cmpd biochemical HTS and opt.
Cell Reports, Jun. 23, 2020
Genentech, South San Francisco, CA
“Compound 2”
1 min read
“Compound 2” binds to a lipid pocket on TEAD transcription factors, transforming TEAD from a transcriptional co-activator to a dominant-negative transcriptional repressor of Hippo pathway signaling. The tool molecule demonstrates activity against xenograft models, and will be useful for understanding Hippo pathway biology.
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