The Merck KGaA MCT4 chemical probe, “compound 18n” , is a novel inhibitor of the monocarboxylate transporter MCT4. Large quantities of lactic acid need to be transported out of tumor cells due to their dependence on glucose metabolism, and this transport is mediated by MCTs. Overexpression of MCT4 is a marker for poor prognosis in cancer, and [...]
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Oct. 6, 2021
Compound 18n: A Monocarboxylate Transporter 4 Inhibitor
"compound 18n"
monocarboxylate transporter 4 inhibitor in vivo PD but limited eff. in xenograft model from cell-based screen and opt. Journal of Medicinal Chemistry Merck Healthcare KGaA, Darmstadt, Germany
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