nanomolar HIV-1 maturation inhibitor
interesting structure
derivative of GSK3532795/BMS955176
Bioorg. Med. Chem. Lett., Jan. 26, 2021
Bristol Myers Squibb, CT + NJ
“compound 16”
1 min read
The BMS HIV-1 maturation inhibitor, “compound 16,” is a potent derivative of the clinical candidate GSK3532795/955176, with double-digit nanomolar activity in cells. The spiro[3.3]hept-5-ene effectively replaces a phenyl ring its parent molecule. Though it wasn’t taken beyond an in vitro assay, the structure is worth noting in the mental isostere toolbox.
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