"Compound 14d ” is a Highly Potent AMPK Activator
compound 14d
β2-AMPK activator in vivo efficacy in diabetic mouse model scaffold hopping from MK-8722 + opt. Bioorg. Med. Chem. Lett., 17 November 2022 Shionogi & Co., Osaka, JP
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seladelpar
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orforglipron
Orforglipron is an oral non-peptide glucagon-like peptide-1 (GLP-1) receptor partial agonist that entered Ph. III for obesity and type-2-diabetes mellitus (T2DM). This 2020 and 2023 Molecule of the Year nominee (nominated initially back when it was still in Ph. I) was first discovered by Chugai Pharmaceuticals under the name OWL833, then licensed by Eli Lilly for worldwide development under the name LY3502970. The article discusses where it sits in the GLP-1R agonist landscape, why it’s scientifically notable, how it works with illustrations from cryo-EM structures, its synthesis, and more.
