elective NNMT inhibitor

100-times higher inhibitory activity than original peptide

peptide library screening, de novo design and SBDD

J. Med. Chem.

Shionogi Pharmaceutical Research Center, Toyonaka, JP

Compound 14 Chemical Structure elective NNMT inhibitor - Shionogi Pharmaceutical Research Center, Toyonaka, JP

Context. “Compound 14” (Shionogi Pharmaceuticals) is a nicotinamide N-methyltransferase (NNMT) inhibitor. For some “difficult to drug” targets such as protein-protein interactions, peptides are attractive therapeutic modalities due to their…


get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: