elective NNMT inhibitor
100-times higher inhibitory activity than original peptide
peptide library screening, de novo design and SBDD
J. Med. Chem.
Shionogi Pharmaceutical Research Center, Toyonaka, JP
Context. “Compound 14” (Shionogi Pharmaceuticals) is a nicotinamide N-methyltransferase (NNMT) inhibitor. For some “difficult to drug” targets such as protein-protein interactions, peptides are attractive therapeutic modalities due to their…