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Sep. 18, 2021

Compound 12j: A Potent Agonist of the Ghrelin Hormone Receptor

"compound 12j"

potent ghrelin receptor full agonist for atrophy/cachexia, not advanced due to PK from HTS and ligand-based design J. Med. Chem., Aug. 12, 2020 Astrazeneca, Molndal, SE

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Drug Hunter Team

“compound 12j” is a potent agonist of the ghrelin hormone receptor, activation of which stimulates growth hormone secretion and appetite among other activities. Ghrelin receptor antagonists have previously been explored to treat disorders related to obesity such as diabetes, but an agonist could be useful in treating atrophic disorders like [...]

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