Chemical structure of compound 10 Genentech XIAP E3-ligase degrader

XIAP E3-ligase degrader via SM ubiquitylation

novel mechanism of induced degradation

from derivatization of XIAP-binder

Journal of the American Chemical Society

Genentech, San Francisco, US

The Genentech XIAP E3-ligase degrader, compound 10, has an interesting mechanism of action, triggering the degradation of its target (XIAP) by ubiquitylation of the small molecule. The molecule behaves as…


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