The Genentech XIAP E3-ligase degrader, compound 10 , has an interesting mechanism of action, triggering the degradation of its target (XIAP) by ubiquitylation of the small molecule. The molecule behaves as a lysine mimetic, accepting ubiquitin from the targeted E3 complex, promoting XIAP’s own degradation. As E3 ligases are often difficult to [...]
Compound 10: a XIAP E3-Ligase Degrader
"compound 10"
XIAP E3-ligase degrader via SM ubiquitylation novel mechanism of induced degradation from derivatization of XIAP-binder Journal of the American Chemical Society Genentech, San Francisco, US