Chemical structure of compound 10 Janssen gut-restricted COX-2 inhibitor

gut-restricted, selective COX-2 inhibitor

in vivo showed no inhibition of gut COX-2

from modification of etoricoxib

Journal of Medicinal Chemistry

Janssen, Spring House, US

The Janssen gut-restricted COX-2 inhibitor, compound 10, is a tool compound used to test the hypothesis that gut-restricted COX-2 inhibition would be beneficial for cancer without the cardiovascular risk of…

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