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Dec. 16, 2021

Compound 10: a COX-2 Inhibitor

"compound 10"

gut-restricted, selective COX-2 inhibitor in vivo showed no inhibition of gut COX-2 from modification of etoricoxib Journal of Medicinal Chemistry Janssen, Spring House, US

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Drug Hunter Team

The Janssen gut-restricted COX-2 inhibitor, compound 10 , is a tool compound used to test the hypothesis that gut-restricted COX-2 inhibition would be beneficial for cancer without the cardiovascular risk of systemic COX-2 inhibition. Unfortunately, IVIVC of several compounds demonstrated that in vivo efficacy was not driven by gut COX-2 [...]

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