The Janssen gut-restricted COX-2 inhibitor, compound 10 , is a tool compound used to test the hypothesis that gut-restricted COX-2 inhibition would be beneficial for cancer without the cardiovascular risk of systemic COX-2 inhibition. Unfortunately, IVIVC of several compounds demonstrated that in vivo efficacy was not driven by gut COX-2 [...]
< 1 minute read
Dec. 16, 2021
Compound 10: a COX-2 Inhibitor
"compound 10"
gut-restricted, selective COX-2 inhibitor in vivo showed no inhibition of gut COX-2 from modification of etoricoxib Journal of Medicinal Chemistry Janssen, Spring House, US