molecules of the month

“Compound 10”

class I sel. histone deacetylase (HDAC) inhib.

in vitro HIV reactivation for HIV eradication

from structure-based design of prior ligand

ACS Med. Chem. Lett., Jun. 22, 2020

Merck & Co., Kenilworth, NJ / West Point

Structure of compound 10
1 min read

“Compound 10” is a potent and selective inhibitor of Class I histone deacetylases (HDAC1/2/3) which increases HIV activity in treatment-suppressed patient immune cells for the goal of eradicating HIV from latent reservoirs. Fascinatingly, the compound 10 actually binds to a zinc ion in the HDAC proteins through a ketone hydrate, formed in situ from a ketone. Definitely a co-crystal structure worth taking a look at.

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