compound 1 is a CD33 pre-mRNA splicing modulator that increases CD33 exon 2 skipping in cells. CD33/Siglec 3 regulates microglia activity, and genetic alterations of CD33 are associated with protection from Alzheimer’s. Alternative splicing of CD33 with exclusion of exon 2 is hypothesized to copy the protective effect of the human genetic [...]
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Feb. 13, 2022
Compound 1: a CD33 Pre-mRNA Splicing Modulator That Increases CD33 Exon 2 Skipping in Cells
compound 1
CD33 splicing modulator preclinical (neurodegeneration) from 3.1M cmpd phenotypic CD33 splicing screen ACS Med. Chem. Lett. Pfizer Inc.
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