The Janssen non-ATP competitive HPK1 inhibitor, “ compound 1 ,” was identified from a screening cascade specifically looking for allosteric inhibitors, which may provide a selectivity advantage over ATP-competitive starting points. Reviewer Adi Murthy says, [...]
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Dec. 10, 2021
A Non-ATP Competitive HPK1 inhibitor from Janssen
compound 1
selective inhibitor of unphosphorylated HPK1 non-ATP competitive, IC50 = 1.2 µM from 700k cmpd HTS for non-ATP comp. inh. Biochemistry Janssen R&D, Spring House, PA