CRBN-based TRK kinase fusion prot. degrader
degrad. of mult. TRK fusions (e.g. TPM3-TRKA)
from functionalization of lit. TRK inhibitor
J. Med. Chem., Oct. 15, 2020
Cullgen Inc., San Diego, CA / Shanghai, CN
CG428
CG428 (Cullgen CRBN-based TRK kinase fusion protein degrader)