CRBN-based TRK kinase fusion prot. degrader

degrad. of mult. TRK fusions (e.g. TPM3-TRKA)

from functionalization of lit. TRK inhibitor

J. Med. Chem., Oct. 15, 2020

Cullgen Inc., San Diego, CA / Shanghai, CN

Structure of CG428

CG428 (Cullgen CRBN-based TRK kinase fusion protein degrader)

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