BMS-986399 structure

oral nonbile acid FXR agonist

FGF15 induction in a BDL mouse modelSBDD

oral nonbile acid FXR agonist

J. Med. Chem.

Biocon-Bristol Myers Squibb Research and Development Center, Bangalore, IN

Context. BMS-986339 (BMS) is an oral farnesoid X receptor (FXR) agonist being developed for nonalcoholic steatohepatitis (NASH). Considered the master regulator of bile acid homeostasis, the nuclear receptor FXR…

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