BAY 1003803 is a potent topical agonist of the glucocorticoid receptor (GR) transrepression pathway, with less activity on the GR transactivation pathway mediated by GR dimers, which may lead to undesirable side effects. The fluoroaminoquinoline was the only heterocycle among analogs tested that was Ames-negative. The compound appears to have [...]
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Sep. 18, 2021
BAY 1003803: A Non-Steroid Glucocorticoid Receptor Modulator
BAY 1003803
non-steroid glucocorticoid receptor modulator completed Ph. I as topical agent in psoriasis from optimization of prior lead Bioorg. Med. Chem. Lett., Jun. 1, 2020 Bayer AG, Berlin, DE / AstraZeneca