AZD8154

inhaled dual PI3K_,_ kinase inhibitor

Ph. II (3 mg QD) for asthma; withdrawn

from re-opt. of oral PI3K_ inhibitor

Journal of Medicinal Chemistry

AstraZeneca, Gothenburg, SE

7. The AstraZeneca inhaled dual PI3K_,_ inhibitor AZD8154 is long-acting in the lung but has low systemic exposure and is selective, potentially avoiding the known side effects of systemic…


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