JAK1-selective kinase inhibitor

in clinical development for cancer

from HTS and SBDD of promiscuous hit

J. Med. Chem., Apr. 28, 2020

AstraZeneca, Waltham, MA

AZD4205 is a JAK1-selective kinase inhibitor which is in clinical development for oncology rather than the inflammatory diseases most JAK1 inhibitors have aimed for. The compound has excellent PK in…

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