© Rosalind Scientific LLC 2018-2022
© Rosalind Scientific LLC, 2018-2022
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oral RORC2 inverse agonist for psoriasis
100 mg PO BID, Ph. I term. due to preclin. Data
from opt. of lit. inverse agonist
Journal of Medicinal Chemistry
AstraZeneca, Gothenburg, Sweden
The AstraZeneca oral RORgt inverse agonist, AZD0284, is an inverse agonist of the nuclear receptor RORC2 (RORγt). Reviewer Chris Gampe says, “targeting the activation and function of Th17 cells has been successful…
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