oral RORC2 inverse agonist for psoriasis

100 mg PO BID, Ph. I term. due to preclin. Data

from opt. of lit. inverse agonist

Journal of Medicinal Chemistry

AstraZeneca, Gothenburg, Sweden


The AstraZeneca oral RORgt inverse agonist, AZD0284, is an inverse agonist of the nuclear receptor RORC2 (RORγt). Reviewer Chris Gampe says, “targeting the activation and function of Th17 cells has been successful…

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