oral RORC2 inverse agonist for psoriasis
100 mg PO BID, Ph. I term. due to preclin. Data
from opt. of lit. inverse agonist
Journal of Medicinal Chemistry
AstraZeneca, Gothenburg, Sweden
AZD0284
The AstraZeneca oral RORgt inverse agonist, AZD0284, is an inverse agonist of the nuclear receptor RORC2 (RORγt). Reviewer Chris Gampe says, “targeting the activation and function of Th17 cells has been successful…