ASP5286 is an analog of the natural product cyclosporin A that maintains the anti-HCV activity of cyclosporin A by binding to cyclophilin, but was optimized to be less immunosuppresive than cyclosporin A. The macrocycle was identified through semisynthetic derivitization of a related natural product, FR901459. The Astellas team was able to [...]
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Sep. 18, 2021
ASP5286: A Non-Immunosuppressive Cyclophilin Inhibitor
ASP5286
non-immunosuppressive cyclophilin inhibitor oral activity in humanized HCV model from semisynthetic deriv. of FR901459 Bioorg. Med. Chem. Lett., Jun. 2, 2020 Astellas Pharma, Ibaraki, JP
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