< 1 minute read
Dec. 20, 2021

ASP2453: An Oral KRAS(G12C) Inhibitor

ASP2453

oral drug, covalent inhibitor of KRASG12C effective in KRASG12C-mutated cancer models SBDD utilizing KRAS proto-oncogene, GTPase British Journal of Cancer Astellas Pharma Inc.

drughunter.com
Drug Hunter Team

The Astellas KRAS^G12C^ covalent inhibitor, ASP2453, is an oral molecule with activity in preclinical mouse models of KRASG12C-mutated cancer at lower doses than sotorasib (AMG 510). Several KRAS inhibitors have been highlighted recently. ASP2453 possesses an interesting spirocyclic azetidine-containing acrylamide warhead, and the [...]

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