Chemical structure of molecule AS-0141 Carna Biosciences CDC7 kinase inhibitor

oral, slow-off, selective CDC7 kinase inhibitor

Ph. I candidate for solid tumors

from HTS and PK optimization

Journal of Medicinal Chemistry

Carna Biosciences, Kobe, JP

The Carna Biosciences CDC7 kinase inhibitor, AS-0141, is a clinical candidate for cancer with a structure that contains a hydrazine, furenone, and ester, all rare functional groups for an oral…


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