The Carna Biosciences CDC7 kinase inhibitor, AS-0141 , is a clinical candidate for cancer with a structure that contains a hydrazine, furenone, and ester, all rare functional groups for an oral molecule. The molecule has a long residence time on the kinase, and despite a short half-life in mouse, extended target engagement is observed >24 h [...]
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Dec. 10, 2021
AS-0141: A CDC7 Kinase Inhibitor
AS-0141
oral, slow-off, selective CDC7 kinase inhibitor Ph. I candidate for solid tumors from HTS and PK optimization Journal of Medicinal Chemistry Carna Biosciences, Kobe, JP
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