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Nov. 26, 2021

ARD-2585: A Bifunctional AR Degrader

ARD-2585

oral CRBN-based androgen receptor degrader preclinical eff. at 10 mpk QD (xenograft) from previously disclosed AR molecule Journal of Medicinal Chemistry University of Michigan

drughunter.com
Drug Hunter Team

The Michigan bifunctional degrader, ARD-2585 , is similar to the Arvinas molecule, ARV-110 that was recently disclosed at AACR 2021. ARV-110 is a first-in-class, potent, and orally active AR degrader in clinical development, but understandably hasn’t had much published on it yet given the competitive environment. The publication of ARD-2585 [...]

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