The Michigan bifunctional degrader, ARD-2585 , is similar to the Arvinas molecule, ARV-110 that was recently disclosed at AACR 2021. ARV-110 is a first-in-class, potent, and orally active AR degrader in clinical development, but understandably hasn’t had much published on it yet given the competitive environment. The publication of ARD-2585 [...]
ARD-2585: A Bifunctional AR Degrader
ARD-2585
oral CRBN-based androgen receptor degrader preclinical eff. at 10 mpk QD (xenograft) from previously disclosed AR molecule Journal of Medicinal Chemistry University of Michigan