ABBV-318, oral CNS-penetrant Nav1.7/1.8 blocker - AbbVie, North Chicago, IL

oral CNS-penetrant Nav1.7/1.8 blocker

in vivo efficacy in rodent pain models

electrophysiology-based HTS and opt.

Bioorg. Med. Chem.

AbbVie, North Chicago, IL

Context. ABBV-318 (AbbVie) is a CNS-penetrating, oral inhibitor of Nav1.7/Nav1.8 being developed for pain treatment. Despite being a highly validated pain target due to its important role in excitable…

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