Topliss Cheat Sheets

This guest post introduces the Topliss schemes for analog synthesis, illustrates when they might be useful, and provides easy-to-use “cheat sheets” of the original schemes. Imagine you’re on a new project that has just conducted a chemical screen on a novel target, and you’re excited to see a few micromolar Read more…

2019 Biologic Drug Approvals

2019 was another big year for novel drug approvals (48 in total) though it wasn’t the record year of 2018 (with 59). The overall explosion in biologic drugs / non-small molecule modalities continued with year with 14 novel biologic drugs, including 3 monoclonal antibodies, a recombinant fusion protein (Reblozyl), 3 Read more…