Terlipressin: Longer Peptide Effect Half-Life via an Active Metabolite
On Monday, Mar. 27th (12:15 PM ET), our Drug Hunter team will be sponsoring a luncheon at ACS Spring 2023 in Indianapolis with a presentation on scientific gems from 2022’s drug approvals (request an invitation here). Each newly approved drug has an interesting scientific story, and you can see our overview of all 36 of…
A Potential Best-in-Class KRASG12C Inhibitor? The Science Behind How Adagrasib Differentiates from Sotorasib
Mirati’s “Breakthrough” KRASG12C inhibitor, adagrasib, was granted accelerated approval by the FDA in 2022. As it follows Amgen’s first-in-class KRASG12C inhibitor, sotorasib, adagrasib is constantly scrutinized for any evidence it may be different, or better, than sotorasib. This deep dive reviews the current understanding on how adagrasib differs from sotorasib and why, including:
First-in-Class Large Molecule Drug Approvals of 2022
You can download our compilation of the 10 first-in-class large molecule drug approvals from 2022 below, which includes structural illustrations, drug targets and mechanisms of action, doses and routes of administration, and indication.
First-in-Class Small Molecule Drug Approvals of 2022
You can download our compilation of the 9 first-in-class small molecule drug approvals from 2022 below, which includes structures, drug targets and mechanisms of action, doses and routes of administration, and indication.
2022 Novel Large Molecule Drug Approvals
You can download our compilation of all 17 large molecule drug approvals from 2022 below, which includes structural illustrations, drug targets and mechanisms of action, doses and routes of administration, and indication. You can also find past examples of our 2021 Large Molecule Approvals Review, 2020 Large Molecule Approvals Compilation and 2019 Large Molecule Approvals…
2022 Novel Small Molecule Drug Approvals
In 2022 there were 36 novel small molecule and large molecule drugs approved by the FDA, including 19 small molecule drug approvals. You can download our compilation of all 19 small molecule drug approvals from 2022 below, which includes structures, drug targets and mechanisms of action, doses and routes of administration, and indication. You can…