Molecules in Motion: An Oral G12D Inhibitor and Allosteric Cbl-b Inhibitor Entering Development
Our latest roundup of small molecules in the news includes three molecules moving into development for the first time: MRTX1133 Mirati’s reversible, long-acting KRASG12D inhibitor, and December ‘21 Molecule of the Month, is going into the clinic as an oral compound. While initial disclosures referred to its potential as an IV agent, Mirati recently announced…
A Billion-Dollar Aldosterone Synthase Inhibitor, an Oral KRASG12D Inhibitor Entering Development, and 14 More Molecules in the News
In this update of small molecules in the news we will cover recent: Want updates like this straight to your inbox? Sign up for our weekly newsletter here. Million-Dollar Molecules baxdrostat This highly selective, oral aldosterone synthase (CYP11B2) inhibitor is being acquired by AstraZeneca via CinCor in a $1.8B transaction. The molecule is in several…
2022 Molecules of the Year: Nominate!
The final set of Molecules of the Month for 2022 is out, and now it’s time to nominate your favorite molecules for 2022’s Molecules of the Year! Nominees should have either been first disclosed in 2022 or had a major new update in 2022 (e.g. clinical trial readout, publication, business transaction, approval). The molecule must…
First-in-Class Large Molecule Drug Approvals of 2022
You can download our compilation of the 10 first-in-class large molecule drug approvals from 2022 below, which includes structural illustrations, drug targets and mechanisms of action, doses and routes of administration, and indication.
First-in-Class Small Molecule Drug Approvals of 2022
You can download our compilation of the 9 first-in-class small molecule drug approvals from 2022 below, which includes structures, drug targets and mechanisms of action, doses and routes of administration, and indication.
2022 Novel Large Molecule Drug Approvals
You can download our compilation of all 17 large molecule drug approvals from 2022 below, which includes structural illustrations, drug targets and mechanisms of action, doses and routes of administration, and indication. You can also find past examples of our 2021 Large Molecule Approvals Review, 2020 Large Molecule Approvals Compilation and 2019 Large Molecule Approvals…