Drug Hunter – drug discovery, chemistry, and biopharma highlights

Small Molecule Drug Approvals


2019 Small Molecule Drug Approvals

Dennis Hu
December 28, 2019
2019 was another big year for drug discovery, with 26 FDA new drug approvals for small molecules and 3 for antibody-drug-conjugates so far. Chris De Savi put together a great…
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DILI Small Featured 3


Managing Liver Injury (DILI) Risk

Dennis Hu
December 8, 2019
Having a clinical drug-induced liver injury (DILI) signal is a surefire way to kill a drug candidate in non-serious indications like pain or chronic indications like diabetes, and will even…
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pRED CDD Interaction Featured


Unusual Molecular Interactions from the PDB

Dennis Hu
December 1, 2019
Protein-ligand interactions are driven predominantly by strong hydrogen-bonding interactions, de-solvation energetics, and other entropic considerations including ligand lipophilicity. However, the combination of many weaker interactions can contribute to potency, and…
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