This section contains case studies, industry highlights, minireviews, and other articles for drug discovery professionals. Check out the resources page for posters, educational content, lists of drug approvals, and more.
The Fuji Yakuhin FXR/TGR5 non-bile acid dual agonist, compound 20p, simultaneously activates the FXR nuclear receptor and the unrelated TGR5 GPCR…
molecule
2 years ago ●
1 min read
The Eternity Bioscience/Shanghai Hengrui RORγ antagonist, SHR168442, is a skin-restricted, topical compound intended to treat psoriasis. As a master regulator of Th17…
molecule
2 years ago ●
1 min read
The Genentech pan-RAF Type II kinase inhibitor, GNE-9815, is an oral chemical probe and among the most highly kinase-selective inhibitors of RAF reported.…
molecule
2 years ago ●
1 min read
The TSRI/UCSF/Lundbeck pan-ABHD17 serine hydrolase covalent inhibitor, ABD957, impairs N-Ras depalmitoylation in AML cells, reducing N-Ras signaling and growth of NRAS-mutant…
molecule
2 years ago ●
1 min read
1.The Lilly glucagon-like peptide-1 receptor (GLP-1R) agonist (LSN3318839) is a positive allosteric modulator intended to treat type 2 diabetes. This…
molecule
1 year ago ●
1 min read
The Galapagos-Servier selective ADAMTS-5 metalloproteinase inhibitor (GLPG1972) recently completed a Ph. II study for knee osteoarthritis. Identification of small molecule…
molecule
2 years ago ●
1 min read
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