This section contains case studies, industry highlights, minireviews, and other articles for drug discovery professionals. Check out the resources page for posters, educational content, lists of drug approvals, and more.
The BMS AAK1 kinase inhibitor, compound 59, is brain-penetrant and acts on the CNS. The target was identified from a phenotypic…
molecule
1 year ago ●
1 min read
The Genentech PI3Kα isoform-selective kinase inhibitor and mutant PI3Kα degrader GDC-0077 (inavolisib) selectively depletes the oncogenic mutant p110α catalytic subunit of PI3Kα…
molecule
2 years ago ●
2 mins read
The Hanmi/Genentech type II RAF kinase inhibitor, belvarafenib, is a potent and selective inhibitor of RAF dimers. GNE-9815 was covered last month,…
molecule
2 years ago ●
2 mins read
The FOLR1-targeting folate receptor-dependent PROTAC conjugate, folate-MS432, is a MEK1/2 degrader that is targeted to FOLR1, a receptor highly expressed in…
molecule
2 years ago ●
1 min read
The Takeda CDC7 serine/threonine kinase inhibitor, simurosertib (TAK-931), is the first orally active CDC7-selective inhibitor and recently had its Ph. I…
molecule
2 years ago ●
2 mins read
The Novartis mutant and WT CFTR potentiator, icenticaftor (QBW251), is an oral Ph. II clinical candidate for chronic obstructive pulmonary disease…
molecule
2 years ago ●
2 mins read
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