This section contains case studies, industry highlights, minireviews, and other articles for drug discovery professionals. Check out the resources page for posters, educational content, lists of drug approvals, and more.
The AstraZeneca ATR serine/threonine kinase inhibitor, ceralasertib (AZD6738), is a potent (1 nM biochemical IC50), orally bioavailable, ATP-competitive inhibitor, and is…
molecule
1 year ago ●
2 mins read
The Vincerx Pharma/Bayer CDK9 inhibitor, VIP152 (BAY 1251152), is a once-weekly (5-30 mg) IV agent in Ph. I for cancer with >50x…
molecule
1 year ago ●
1 min read
The Takeda AMPA-R potentiator, TAK-653, is a glutamate-dependent potentiator that exhibits minimal agonism. AMPA-R agonism is associated with seizure risk and…
molecule
1 year ago ●
1 min read
The Takeda brain-penetrant M1R positive allosteric modulator (PAM), TAK-071, was optimized for lower cooperativity (α) with the native ligand to…
molecule
1 year ago ●
1 min read
The Takeda GPR139 agonist, TAK-041, is a CNS-penetrant GPCR agonist being explored for schizophrenia symptoms and is an interesting example of…
molecule
1 year ago ●
1 min read
The Altos Therapeutics/Takeda D2/D3 receptor antagonist, TAK-906, is a peripherally-restricted, non-BBB penetrant molecule, targeting the stomach and vomiting center in the area…
molecule
1 year ago ●
2 mins read
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