This section contains case studies, industry highlights, minireviews, and other articles for drug discovery professionals. Check out the resources page for posters, educational content, lists of drug approvals, and more.
The Deciphera CSF1R kinase inhibitor, vimseltinib (DCC-3014), is a selective oral TKI that induces an inactive conformation of CSF1R by biomimetically nucleating…
molecule
1 year ago ●
1 min read
The Michigan bifunctional degrader, ARD-2585, is similar to the Arvinas molecule, ARV-110 that was recently disclosed at AACR 2021. ARV-110 is…
molecule
1 year ago ●
1 min read
The AstraZeneca PARP1-DNA trapper, AZD5305, is a phase I candidate (NCT04644068) for cancer that is selective for PARP1 over PARP2 (>500x). Their…
molecule
1 year ago ●
1 min read
The Sanofi S1P1 agonist, SAR247799, is a biased agonist of the S1P1 sphingosine receptor, preferentially activating G-protein signaling over the β-arrestin…
molecule
1 year ago ●
1 min read
The ImmunoMet OXPHOS modulator (PC1 inhibitor), IM156, is a derivative of the long-used biguanide diabetes drug, metformin, that appears to have…
molecule
1 year ago ●
1 min read
The BMS BET inhibitor, BMS-986158, is in a Ph. I/IIa trial in advanced cancers. During the optimization of the molecule from…
molecule
1 year ago ●
1 min read
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