This section contains case studies, industry highlights, minireviews, and other articles for drug discovery professionals. Check out the resources page for posters, educational content, lists of drug approvals, and more.
Context. NVP-CLR457 (Novartis Institutes for BioMedical Research) is an oral, non-CNS-penetrating pan-class IA phosphoinositide 3-kinase (PI3K) inhibitor. Due to the…
molecule
10 months ago ●
6 mins read
Having a clinical drug-induced liver injury (DILI) signal is a surefire way to kill a drug candidate in non-serious indications…
Article
3 years ago ●
6 mins read
Context. TXA6101 (TAXIS Pharmaceuticals) is a filamentous temperature-sensitive mutant Z (FtsZ) protein inhibitor being developed for targeting gram-negative bacteria. Drug…
molecule
10 months ago ●
4 mins read
The C-H --- O hydrogen bond is so well established in structural biology today, that it's been overlooked that the…
Article
3 years ago ●
4 mins read
Context. RLX-33 (Research Triangle Institute) is a nonpeptide relaxin-3/RXFP3 system antagonist. Evidence over the last 2 decades, since the discovery…
molecule
10 months ago ●
4 mins read
The global cancer immunotherapy pipeline continues to explode with nearly double the number of active targets in 2019 vs. only…
Article
4 years ago ●
3 mins read
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