This section contains case studies, industry highlights, minireviews, and other articles for drug discovery professionals. Check out the resources page for posters, educational content, lists of drug approvals, and more.
Targeting 20-HETE/GPR75 via Selective CYP Inhibition: A 20+ Year-Old Kidney Program from Taisho The arachidonic acid (AA) metabolite, 20-hydroxy-5,8,11,14-eicosatetranoic acid…
molecule
1 month ago ●
5 mins read
An Active Prodrug, Triple Reuptake Inhibitor for Major Depressive Disorder While SNRIs and selective serotonin reuptake inhibitors (SSRIs) have been…
molecule
1 month ago ●
11 mins read
By Dennis KoesterReviewed and edited by Michael Walters and Dennis Hu Obtaining adequate drug exposure in the brain is key…
resource
1 month ago ●
31 mins read
The First Disclosures sessions at the 2023 ACS Fall Meeting in San Francisco, organized by Nikki Goodwin, presented a variety…
Article
1 month ago ●
2 mins read
LRRK2 has been a hotly pursued drug target for Parkinson’s Disease based on human genetics. Clinical advancement of LRRK2 inhibitors…
Article
2 months ago ●
4 mins read
Ritlecitinib: A deceptively simple structure hides a complex covalent drug discovery story Pfizer’s ritlecitinib (PF-06651600), a first-in-class, selective, oral covalent…
molecule
2 months ago ●
12 mins read
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