This section contains case studies, industry highlights, minireviews, and other articles for drug discovery professionals. Check out the resources page for posters, educational content, lists of drug approvals, and more.
A covalent KRASG12R inhibitor used as a proof-of-concept for covalent arginine modification, an oral dihydroorotate dehydrogenase inhibitor being developed for…
Article
12 months ago ●
1 min read
Revumenib: a novel Menin-MLL1 inhibitor in Ph. II for AML. Acute myeloid leukemia (AML) remains difficult to treat, with few…
molecule
5 months ago ●
7 mins read
In August 2022, olipudase alfa (Xenpozyme), a hydrolytic lysosomal sphingomyelin-specific enzyme indicated for non–CNS manifestations of acid sphingomyelinase deficiency (ASMD),…
Article
12 months ago ●
6 mins read
A p38α-MK2 kinase complex inhibitor for inflammation. Zunsemetinib (ATI-450, CDD-450) is a p38α-MK2 complex inhibitor discovered by Confluence Technologies and…
molecule
5 months ago ●
6 mins read
In August 2022, the European Medicines Agency granted Marketing Authorization to lenacapavir (Sunlenca), the first-in-class bi-annually dosed HIV capsid inhibitor…
Article
12 months ago ●
6 mins read
The first dengue NS3-NS4B inhibitor to enter the clinic. Recently disclosed in Nature, Janssen’s JNJ-1802 is the first dengue virus…
molecule
5 months ago ●
8 mins read
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