This section contains case studies, industry highlights, minireviews, and other articles for drug discovery professionals. Check out the resources page for posters, educational content, lists of drug approvals, and more.
What is it? Compound 49 is an orally available CD73 inhibitor with dose-dependent PK/PD and an immune-mediated antitumor mechanism of…
molecule
2 months ago ●
3 mins read
A first-in-class intravenous kappa opioid receptor (KOR) agonist, an oral soluble guanylate cyclase (sGC) stimulator, a first-in-class subcutaneous complement C3…
Article
9 months ago ●
15 mins read
Toward a first-in-class DGAT2 inhibitor for the treatment of NASH. Hepatic triglyceride (TG) accumulation is a symptom of non-alcoholic fatty…
molecule
3 months ago ●
4 mins read
This deep dive into 2021’s first-in-class large molecule drug approvals is the third in a series of focus articles on…
Article
9 months ago ●
21 mins read
An oral, brain-penetrant splicing modulator targeting ELP1. Incorrect splicing of the Elongator complex protein 1 (ELP1) gene causes Familial Dysautonomia…
molecule
3 months ago ●
3 mins read
Readers have been asking for more molecules, so this month, we’re starting a new feature that will highlight a few…
Article
9 months ago ●
6 mins read
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